International Journal of Hematology

DOI: 10.1007/BF02982108 Pages: 466-472

Transcriptional Regulation of Myelopoiesis

1. Johns Hopkins University, Division of Pediatric Oncology

Correspondence to:
Alan D. Friedman
Tel: 410-955-2095
Fax: 410-955-8897
Email: adfrdman@jhmi.edu)

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Abstract

A common myeloid progenitor gives rise to both granulocytes and monocytes. The early stages of granulopoiesis are mediated by the C/EBPα, PU.1, RAR, CBF, and c-Myb transcription factors, and the later stages require C/EBPε, PU.1, and CDP. Monocyte development requires PU.1 and interferon consensus sequence binding protein and can be induced by Maf-B, c-Jun, or Egr-1. Cytokine receptor signals modulate transcription factor activities but do not determine cell fates. Several mechanisms orchestrate the myeloid developmental program, including cooperative gene regulation, protein:protein interactions, regulation of factor levels, and induction of cell cycle arrest.

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