International Journal of Hematology

DOI: 10.1007/s12185-010-0737-z Pages: 118-122

Repeated donor lymphocyte infusions overcome a myeloid sarcoma of the stomach resulting from a relapse of acute myeloid leukemia after allogeneic cell transplantation in long-term survival of more than 10 years

1. Sapporo Hokuyu Hospital, Department of Hematology

2. University of Toyama, Third Department of Internal Medicine, Graduate School of Medicine

Correspondence to:
Akinori Wada
Tel: +81-76-4347301
Fax: +81-76-4345027
Email: akino@med.u-toyama.ac.jp

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Abstract

A patient with acute myeloid leukemia had a relapse with a myeloid sarcoma of the stomach 32 months after allogeneic bone marrow transplantation. The patient was treated with the first donor lymphocyte infusion (DLI) and one course of induction chemotherapy. Due to severe infectious complication after chemotherapy, the patient could not continue chemotherapy. Subsequently, the patient was treated with a total of 13 cycles of DLI at 1–2 month intervals. Complete remission was achieved and neither relapse nor graft versus host disease has occurred during a follow-up of more than 10 years.

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