International Journal of Hematology

DOI: 10.1007/s12185-010-0743-1 Pages: 21-26

Iron and erythropoiesis: a dual relationship

1. Università Vita-Salute e IRCCS San Raffaele, Division of Genetics and Cell Biology

Correspondence to:
Clara Camaschella
Tel: +39-02-26437782
Fax: +39-02-26432640
Email: clara.camaschella@hsr.it

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Abstract

Iron is essential for cell life and especially for erythropoiesis which is the major body consumer of iron for red cell production. The study of genetic disorders of iron metabolism, the identification of iron transporters and of the role of hepcidin as the key regulator of systemic iron homeostasis have greatly contributed to our understanding of iron handling by the erythroid marrow. Spontaneous and engineered animal models of iron disorders have help to add further insights to the issue. A still incompletely understood aspect remains the regulation that erythropoiesis exerts on iron.

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