International Journal of Hematology

DOI: 10.1007/s12185-011-0905-9 Pages: 134-141

Deregulated transcription factors in leukemia

1. National Cancer Center Research Institute, Division of Hematological Malignancy

Correspondence to:
Issay Kitabayashi
Tel: +81-3-35475274
Fax: +81-3-35420688
Email: ikitabay@ncc.go.jp

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Abstract

Specific chromosomal translocations and other mutations associated with acute myeloblastic leukemia (AML) often involve transcription factors and transcriptional coactivators. Such target genes include AML1, C/EBPα, RARα, MOZ, p300/CBP, and MLL, all of which are important in the regulation of hematopoiesis. The resultant fusion or mutant proteins deregulate the transcription of the affected genes and disrupt their essential role in hematopoiesis, causing differentiation block and abnormal proliferation and/or survival. This review focuses on such transcription factors and coactivators, and describes their roles in leukemogenesis and hematopoiesis.

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