International Journal of Hematology

DOI: 10.1007/s12185-012-1243-2 Pages: 98-102

Prognosis of mature T cell lymphoma is poorer than that of diffuse large B cell lymphoma in IPI low-risk group, but not in intermediate- and high-risk groups

1. Clinical Hematology Group of National Hospital Organization (CHG-NHO)

2. National Hospital Organization Nagoya Medical Center, Clinical Research Center

3. Aichi Gakuin University, Faculty of Psychological and Physical Science

4. National Hospital Organization Tokyo Medical Center

5. National Hospital Organization Kyushu Cancer Center

6. National Hospital Organization Kyushu Medical Center

7. National Hospital Organization Kumamoto Medical Center

8. National Hospital Organization Kagoshima Medical Center

9. National Hospital Organization Okayama Medical Center

10. National Hospital Organization Osaka Medical Center

11. National Hospital Organization Nishigunma National Hospital

12. National Hospital Organization Nagasaki Medical Center

13. National Hospital Organization Hiroshima-nishi Medical Center

14. National Hospital Organization Matsumoto Medical Center

Correspondence to:
Hirokazu Nagai
Tel: +81-52-951-1111
Fax: +81-52-951-9075
Email: nagaih@nnh.hosp.go.jp

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Abstract

Mature T cell lymphoma has been noted for poor prognosis when compared with B cell lymphoma, even in the pre-rituximab era. To confirm this difference, a retrospective cohort study was conducted. One hundred-and nineteen patients with mature T cell lymphoma and 568 patients with diffuse large B cell lymphoma (DLBCL) who did not receive rituximab as first induction were studied. Overall survival (OS) was worse for patients with international prognostic index (IPI) scores indicating low-risk mature T cell lymphoma than for those with DLBCL (3-year OS 87 % vs. 58 %, P = 0.001), but not in other risk groups. Prognosis of mature T cell lymphoma was significantly poorer in the IPI low-risk group, as compared with DLBCL.

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