International Journal of Hematology

DOI: 10.1007/s12185-014-1520-3 Pages: 227-239

Peripheral T cell lymphoma in Asia

1. Ewha Womans University School of Medicine, Department of Pathology and Global Top 5 Research Program

2. Sungkyunkwan University School of Medicine, Department of Pathology, Samsung Medical Center

Correspondence to:
Young Hyeh Ko
Tel: +82-2-34102762
Fax: +82-2-34100025
Email: yhko310@skku.edu

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Abstract

Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T- and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.

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