International Journal of Hematology

DOI: 10.1007/s12185-014-1535-9 Pages: 542-552

Dysregulation of microRNAs and their association in the pathogenesis of T-cell lymphoma/leukemias

1. Akita University Graduate School of Medicine, Department of Hematology, Nephrology, and Rheumatology

Correspondence to:
Hiroyuki Tagawa
Tel: +81-01-8846114
Fax: +81-01-8362613
Email: htagawa0279jp@yahoo.co.jp

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Abstract

MicroRNAs (miRNAs) are non-coding regulatory RNAs consisting of 20–24 nucleotides. Over 4,500 miRNAs have been identified in humans, and it is known that nearly all human protein-encoding genes can be controlled by miRNAs in both healthy and malignant cells. Abnormal miRNA expression is known to occur in many cancers, including in malignant lymphomas (MLs). Detailed genome-wide miRNA expression analysis has been performed in various ML subtypes, and these analyses have led to the discovery of subtype-specific miRNA alterations. Actually, in B-cell lymphomas, several miRNAs have been used as prognostic markers, and their targets are for new agents for ML therapy. Successful studies for delineating miRNA functions in B-cell lymphomas lead us to hypothesize that miRNA dysregulation may also be deeply associated with the pathogenesis of T-cell lymphomas. Indeed, studies for delineating essential miRNAs have been conduced against comparatively well-defined T-cell lymphoma entities. In this review, we describe several key miRNAs and their targets in distinct T-cell lymphoma subsets and their roles in their pathogenesis, studies of which will lead to new therapeutic strategies against T-cell lymphomas.

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