International Journal of Hematology

DOI: 10.1007/s12185-014-1583-1 Pages: 679-684

Regulation of hematopoiesis in endosteal microenvironments

1. Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Hematology, Oncology and Respiratory Medicine

2. Kobe University Hospital, Hematology, Department of Medicine

3. Albert Einstein College of Medicine, Jack and Pearl Resnick Campus

Correspondence to:
Noboru Asada
Tel: +1-718-6781204
Fax: +1-718-6781018



After birth, the hematopoietic system develops along with bone formation in mammals. Osteolineage cells are derived from mesenchymal progenitor cells, and differentiate into several types of bone-forming cells. Of the various types of cell constituents in bone marrow, osteolineage cells have been shown to play important roles in hematopoiesis. Early studies have identified osteoblasts as a hematopoietic stem cell niche component. Since that time, the role of endosteal microenvironment as a critical regulator of hematopoietic stem/progenitor cell (HSC/HPC) behavior has been appreciated particularly under stress conditions, such as cytokine-induced HSC/HPC mobilization, homing/engraftment after bone marrow transplantation, and disease models of leukemia/myelodysplasia. Recent studies revealed that the most differentiated osteolineage cells, i.e., osteocytes, play important roles in the regulation of hematopoiesis. In this review, we provide an overview of recent advances in knowledge of regulatory hematopoietic mechanisms in the endosteal area.

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