International Journal of Hematology

DOI: 10.1007/s12185-014-1588-9 Pages: 695-698

Bone marrow Schwann cells induce hematopoietic stem cell hibernation

1. University of Tokyo, Laboratory of Stem Cell Therapy, Center for Experimental Medicine, The Institute of Medical Science

Correspondence to:
Satoshi Yamazaki
Email: y-sato4@ims.u-tokyo.ac.jp

Close

Abstract

Hematopoietic stem cells (HSCs) are clonogenic cells capable of both self-renewal and multilineage differentiation. In adult mouse bone marrow (BM), most HSCs remain in the non-dividing G0-phase of cell cycle, in close contact with supporting cells known as the HSC “niche”. In the present study, we focused on signaling mechanisms that regulate stem cell dormancy in the BM niche. We show that TGF-β type II receptor deficiency causes reduced phosphorylation of Smad2/3 and impairs long-term repopulating activity in HSCs, suggesting a significant role for TGF-β/Smad signaling in hematopoiesis. Furthermore, we aimed at defining the candidate BM niche responsible for homeostasis of hematopoiesis, and revealed that non-myelinating Schwann cells sustain HSC hibernation by converting TGF-β from its latent to its active form.

This article is freely available, click here to access the full text/PDF

Share the Knowledge