International Journal of Hematology

DOI: 10.1007/s12185-014-1641-8 Pages: 317-325

Aging of the hematopoietic stem cells niche

1. Keio University, Department of Cell Differentiation, The Sakaguchi Laboratory

Correspondence to:
Toshio Suda
Email: sudato@z3.keio.jp

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Abstract

Homeostasis of the hematopoietic system has its roots in the maintenance of hematopoietic stem cells (HSCs) in the bone marrow (BM). HSCs change both phenotypically and functionally with physiological age. The alterations noted in aged HSCs are thought to be a consequence of both cell-intrinsic and extrinsic changes. We review here the age-related changes that the BM microenvironment exerts on HSCs.

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