International Journal of Hematology

DOI: 10.1007/s12185-015-1850-9 Pages: 709-712

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) after treatment for Hodgkin’s lymphoma

1. Keio University School of Medicine, Department of Neurology

2. Keio University School of Medicine, Division of Hematology, Department of Medicine

3. Keio University School of Medicine, Division of Diagnostic Pathology

Correspondence to:
Shigeaki Suzuki
Tel: +81 3 5363 3788
Email: sgsuzuki@z3.keio.jp

Close

Abstract

Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS) is a rare central nervous system (CNS) disorder with distinct radiological features. However, CLIPEERS may mimic CNS lymphoma, and several cases in which CLIPPERS occurred premonitory to CNS lymphoma have been reported. We report a 31-year-old man presenting with progressive gait ataxia and the characteristic MRI features of CLIPPERS. He was diagnosed with stage II Hodgkin’s lymphoma at the age of 15, and we considered the possibility of newly emerged CNS lymphoma occurring in the immunosuppressive condition after the treatment of Hodgkin’s lymphoma. Histological findings showed no evidence of CNS lymphoma and the neurological symptoms were resolved by steroids. Although CLIPPERS developed in the reverse order in this case, CLIPPERS should be considered in different diagnosis for CNS lymphoma.

To access the full text, please Sign in

If you have institutional access, please click here

Share the Knowledge