International Journal of Hematology

DOI: 10.1007/s12185-015-1886-x Pages: 145-154

The role of Eph/ephrin molecules in stromal–hematopoietic interactions

1. University of Adelaide, Mesenchymal Stem Cell Laboratory, School of Medicine, Faculty of Health Sciences

2. South Australian Health and Medical Research Institute

3. SA Pathology, Division of Haematology

Correspondence to:
Stan Gronthos



Bone marrow mesenchymal stromal/stem cells (BMSC) are fundamental regulatory elements of the hematopoietic stem cell niche; however, the molecular signals that mediate BMSC support of hematopoiesis are poorly understood. Recent studies indicate that BMSC and hematopoietic stem/progenitors cells differentially express the Eph cell surface tyrosine kinase receptors, and their ephrin ligands. Eph/ephrin interactions are thought to mediate cross-talk between BMSC and different hematopoietic cell populations to influence cell development, migration and function. This review summarizes Eph/ephrin interactions in the regulation of BMSC communication with hematopoietic stem/progenitor cells and discusses Eph/ephrin-targeted therapeutic strategies that are currently being pursued for various hematotological malignancies.

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