International Journal of Hematology

DOI: 10.1007/s12185-016-1958-6 Pages: 607-616

Cell intrinsic and extrinsic regulation of leukemia cell metabolism

1. Baylor College of Medicine, Department of Molecular and Human Genetics, Program in Developmental Biology

Correspondence to:
Daisuke Nakada
Email: nakada@bcm.edu

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Abstract

Metabolic homeostasis is a fundamental property of cells that becomes dysregulated in cancer to meet the altered, often heightened, demand for metabolism for increased growth and proliferation. Oncogenic mutations can directly change cellular metabolism in a cell-intrinsic manner, priming cells for malignancy. Additionally, cell-extrinsic cues from the microenvironment, such as hypoxia, nutrient availability, oxidative stress, and crosstalk from surrounding cells can also affect cancer cell metabolism, and produce metabolic heterogeneity within the tumor. Here, we highlight recent findings revealing the complexity and adaptability of leukemia cells to coordinate metabolism.

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