International Journal of Hematology

DOI: 10.1007/s12185-017-2202-8 Pages: 299-303

Successful treatment of histiocytic sarcoma with cladribine and high-dose cytosine arabinoside in a child

1. Niigata University Graduate School of Medical and Dental Sciences, Department of Pediatrics

2. Niigata University Graduate School Medical and Dental Sciences, Department of Orthopedic Surgery

3. Niigata University Graduate School Medical and Dental Sciences, Department of Pathology

Correspondence to:
Chihaya Imai
Tel: +81-25-227-2222
Email: chihaya@med.niigata-u.ac.jp

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Abstract

Histiocytic sarcoma, a rare hematopoietic neoplasm with evidence of histiocytic differentiation, is often refractory to conventional chemotherapy and radiotherapy, and its prognosis is generally dismal. The optimal management of this malignancy has not been established. We report a case of 8-year-old girl with histiocytic sarcoma involving the left femur. The tumor rapidly responded to a combination of cladribine and high-dose cytosine arabinoside, an aggressive salvage regimen for refractory Langerhans cell histiocytosis, and became impalpable during the first cycle. The patient has remained in complete remission more than 7 years from diagnosis.

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