International Journal of Hematology

DOI: 10.1007/s12185-017-2219-z Pages: 266-268

Prophylactic use of octreotide for asparaginase-induced acute pancreatitis

1. Juntendo University Faculty of Medicine, Department of Pediatrics

2. Okinawa Prefectural Nanbu Medical Center Children’s Medical Center, Department of Pediatric Hematology and Oncology

Correspondence to:
Sachi Sakaguchi
Tel: 03-3813-3111
Email: sachi@juntendo.ac.jp

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Abstract

In the present study, we sought to evaluate the prophylactic use of octreotide for asparaginase-induced acute pancreatitis. We reviewed the medical records of seven patients in two institutions who received prophylactic octreotide for re-administration of asparaginase after asparaginase-induced acute pancreatitis. Three patients completed asparaginase treatment without developing pancreatitis, and four experienced recurrence of pancreatitis. A literature search using PubMed identified four additional patients in whom asparaginase was successfully re-administered with octreotide. Prophylactic use of octreotide may, thus, be warranted for patients who would benefit from re-administration of asparaginase for cancer treatment; however, careful observation is needed to monitor for breakthrough recurrence of pancreatitis.

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