International Journal of Hematology

DOI: 10.1007/s12185-017-2243-z Pages: 711-719

CMML: Clinical and molecular aspects

1. Assistance Publique, Hopitaux de Paris, Paris Diderot University, Hematology Department, Hopital Saint-Louis

2. INSERM U944, Institut Universitaire d’Hématologie

3. INSERM U1170, Gustave Roussy Cancer Center

4. Gustave Roussy Cancer Center, Hematology Departement

Correspondence to:
Raphael Itzykson
Email: raphael.itzykson@aphp.fr

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Abstract

Chronic Myelomonocytic Leukemia is a chronic myeloid neoplasm occurring mostly in the elderly with overlapping features of myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN) characterized by chronic monocytosis. Recent progresses in the molecular and cellular pathogenesis of CMML have stirred a renewed interest in this clinically heterogeneous disorder. Here, we review the recent progresses in the biology of CMML and how it affects its current and future clinical management.

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