International Journal of Hematology

DOI: 10.1007/s12185-017-2262-9 Pages: 45-54

Complexity of bone marrow hematopoietic stem cell niche

1. Albert Einstein College of Medicine, Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research

2. Albert Einstein College of Medicine, Department of Cell Biology

3. Albert Einstein College of Medicine, Department of Medicine

Correspondence to:
Paul S. Frenette
Tel: +1-718-678-1204
Email: paul.frenette@einstein.yu.edu

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Abstract

Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells throughout the life reside in specialized microenvironment called “niche” in the bone marrow (BM) where they are tightly regulated. With the recent advances in experimental technologies enabling the selective deletion of molecules, various types of cells in the BM have been proposed to contribute to HSC niche activity. Among these are stromal cells closely associated with the vasculature. In this review, we provide an overview of recent advances in HSC niche research, and focus on the studies describing the functional roles of perivascular cells for HSC maintenance and mobilization. Not only for physiologic state, we also discuss the recent evidences suggesting the importance of microenvironment for emergence of malignant hematopoietic diseases.

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