International Journal of Hematology

DOI: 10.1007/s12185-018-2449-8 Pages: 1-6

Clinical characteristics and outcomes of diffuse large B-cell lymphoma in adolescents and young adults

1. National Hospital Organization Nagoya Medical Center, Department of Hematology

2. National Hospital Organization Tokyo Medical Center, Department of Hematology

3. National Hospital Organization Kyushu Cancer Center, Department of Hematology

4. National Hospital Organization Kyushu Medical Center, Department of Hematology

5. National Hospital Organization Kumamoto Medical Center, Department of Hematology

6. National Hospital Organization Kagoshima Medical Center, Department of Hematology

7. National Hospital Organization Okayama Medical Center, Department of Hematology

8. National Hospital Organization Osaka Medical Center, Department of Hematology

9. National Hospital Organization Shibukawa Medical Center, Department of Hematology

10. National Hospital Organization Kure Medical Center, Department of Hematology

11. National Hospital Organization Nagoya Medical Center, Clinical Research Center

12. Gifu Prefectural Tajimi Hospital, Department of Hematology

Correspondence to:
Yasuhiro Suzuki
Tel: +81-52-951-1111
Email: yassuzuki@med.nagoya-u.ac.jp

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Abstract

Clinical information regarding non-Hodgkin lymphoma (NHL) in adolescents and young adults (AYA) is lacking. We retrospectively analyzed 1426 consecutively registered patients with newly diagnosed NHL. Of 798 DLBCL patients, 42 (5.3%) were identified as AYA (16–39 years). The characteristics of AYA DLBCL patients showed no significant differences compared to older adult DLBCL patients (age ≥ 40 years). Progression-free survival (PFS) and overall survival (OS) in AYA were similar to those in patients aged 40–60 years. However, in older adult groups, PFS and OS were significantly different according to the age group (40–60, 61–79, and ≥ 80 years). In univariate analysis in AYA, performance status, clinical stage, International Prognostic Index (IPI), and age-adjusted IPI significantly affected both PFS and OS. In multivariate analysis, only clinical stage was identified as an independent predictor among AYA. In conclusion, disease characteristics and outcomes of DLBCL in AYA were nearly the same as those in older adults.

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