International Journal of Hematology

DOI: 10.1007/s12185-018-2496-1 Pages: 1-7

Invasive Scopulariopsis alboflavescens infection in patient with acute myeloid leukemia

1. Kobe University Hospital, Department of Medical Oncology and Hematology

2. Kobe University Hospital, Division of Infectious Diseases

3. Kobe University Hospital, Department of Transfusion Medicine and Cell Therapy

4. Kobe University Hospital, Department of Infection Control and Prevention

5. Chiba University, Medical Mycology Research Center

Correspondence to:
Keiji Kurata
Tel: +81-78-382-5820
Email: kkurata@med.kobe-u.ac.jp

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Abstract

Scopulariopsis alboflavescens is a soil saprophyte that is widely distributed in nature. Recently, there have been increasing number of reports of invasive infections with Scopulariopsis species in immunocompromised patients. In this report, we described an adult woman with acute myeloid leukemia and who developed S. alboflavescens pneumonia. Liposomal amphotericin B and voriconazole combination therapy was unsuccessful and the patient died because of pneumonia. Scopulariopsis is highly resistant to available antifungal agents and almost invariably fatal. This case report should alert clinicians to the importance of listing Scopulariopsis as a pathogenic fungus in immunocompromised patients.

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