International Journal of Hematology

DOI: 10.1007/s12185-018-2518-z Pages: 1-13

Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

1. Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine

2. Yong Loo Lin School of Medicine, National University of Singapore, Department of Medicine

Correspondence to:
Takaomi Sanda
Tel: +65-6516-1016
Email: takaomi_sanda@nus.edu.sg

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Abstract

TAL1/SCL is a prime example of an oncogenic transcription factor that is abnormally expressed in acute leukemia due to the replacement of regulator elements. This gene has also been recognized as an essential regulator of hematopoiesis. TAL1 expression is strictly regulated in a lineage- and stage-specific manner. Such precise control is crucial for the switching of the transcriptional program. The misexpression of TAL1 in immature thymocytes leads to a widespread series of orchestrated downstream events that affect several different cellular machineries, resulting in a lethal consequence, namely T-cell acute lymphoblastic leukemia (T-ALL). In this article, we will discuss the transcriptional regulatory network and downstream target genes, including protein-coding genes and non-coding RNAs, controlled by TAL1 in normal hematopoiesis and T-cell leukemogenesis.

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