International Journal of Hematology

DOI: 10.1007/s12185-018-2542-z Pages: 125-129

Massive bone marrow necrosis revealing an HIV-related primary bone marrow lymphoma: a diagnostic challenge

1. Aristotle University of Thessaloniki (AUTH), Department of Haematology, First Department of Internal Medicine, Faculty of Medicine, AHEPA General Hospital

2. Aristotle University of Thessaloniki (AUTH), Department of Pathology, Faculty of Medicine, AHEPA General Hospital

Correspondence to:
Maria Papaioannou
Tel: +30-2310-994825



Bone marrow necrosis (BMN) is a condition that can be difficult to diagnose, requiring a hematologist experienced in bone marrow morphology. This diagnostic challenge should alert the clinician of a severe disease or a possible underlying malignancy, either hematological or a solid tumor. We describe the concomitant presence of a primary bone marrow lymphoma (diffuse large B-cell lymphoma—DLBCL), along with an extensive BMN in an HIV patient for the first time in a living individual. HIV infection, BMN and DLBCL presented a multifactorial crossword of molecular events underlying the complex pathophysiology. The exact precipitating pathophysiological events resulting in BMN remain obscure and provide their clear impact for future research. The present report is instructive and also contains a critical review of the literature related to the case presented.

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