International Journal of Hematology

DOI: 10.1007/s12185-019-02656-4 Pages: 375-380

Transformation of follicular lymphoma to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma

1. Kyushu University, Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences

2. Kurume University School of Medicine, Department of Pathology

Correspondence to:
Motoaki Shiratsuchi
Tel: +81-92-642-5281
Email: mshira@intmed3.med.kyushu-u.ac.jp

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Abstract

The frequency of multiple primary malignant neoplasms (MPMN) is increasing due to population aging. Since consensus guidelines for the treatment of MPMN are lacking, treatment strategies are determined by disease status on a per-patient basis. In this report, we describe a case of MPMN with follicular lymphoma (FL) grade 1 that transformed to double-hit lymphoma during adjuvant chemotherapy for concurrent ovarian carcinoma. A 64-year-old woman was diagnosed with MPMN of FL and endometrioid carcinoma by staging laparotomy and lymph node biopsy. She received four cycles of adjuvant chemotherapy (carboplatin and paclitaxel) for endometrioid carcinoma, but during chemotherapy, the FL grade 1 transformed to double-hit lymphoma. We speculate that adjuvant chemotherapy for endometrioid carcinoma may have triggered the transformation of FL in the present case.

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