International Journal of Hematology

DOI: 10.1007/s12185-019-02693-z Pages: 438-446

The Glasgow Prognostic Score is a significant predictor of peripheral T-cell lymphoma (PTCL) treated with CHOP-based chemotherapy and comparable with PTCL prognostic scores

1. Dong-A University College of Medicine, Department of Internal Medicine

2. Gyeongsang National University Hospital, Department of Internal Medicine

3. Samsung Medical Center, Department of Medicine

4. Kosin University Gospel Hospital, Department of Internal Medicine

5. University of Ulsan College of Medicine, Department of Hematology and Oncology

6. Myongji Hospital, Division of Hematology-Oncology, Department of Medicine

7. Kangdong Sacred Heart Hospital, Department of Internal Medicine

Correspondence to:
Jae-Cheol Jo
Tel: 82-51-240-2808



The Glasgow Prognostic Score (GPS) serves a prognostic role in several lymphomas. The objectives of the present study were to determine whether GPS predicts clinical outcomes and to compare the utility of four prognostic scores, including GPS, in patients diagnosed with peripheral T-cell lymphoma (PTCL). We selected for this retrospective study 96 patients consecutively diagnosed with PTCL according to the World Health Organization classification from January 2002 to February 2013 and followed up in five different institutions. Low GPS was a good prognostic biomarker of progression-free survival (PFS, P = 0.030) and overall survival (OS, P = 0.013). Estimated 3-year OS rates (low-risk vs. intermediate- or high-risk) by the International Prognostic Index (IPI), the Prognostic Index for T-cell lymphoma (PIT), the International Peripheral T-cell Lymphoma Project (IPTCLP) score, and GPS were 83% vs. 44% (P < 0.001), 68% vs. 37% (P = 0.004), 71% vs. 26% (P < 0.001) and 68% vs. 51% (P = 0.031), respectively. These results indicate that GPS has prognostic value for PTCL. In addition, all four prognostic scores demonstrate their usefulness in assessing PTCL outcomes.

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