International Journal of Hematology

DOI: 10.1532/IJH97.04113 Pages: 159-161

Isolated Hyperkalemia Associated with Cyclosporine Administration in Allogeneic Stem Cell Transplantation for Renal Cell Carcinoma

1. Kanazawa University Graduate School of Medicine, Departments of Cellular Transplantation Biology

3. Kanazawa University Graduate School of Medicine, Departments of Urology

2. Kanazawa University Graduate School of Medicine, Clinical Laboratory Unit

Correspondence to:
Shinji Nakaoa
Tel: 81-76-265-2275
Fax: 81-76-234-4252
Email: takami@med3.m.kanazawa-u.ac.jp

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Abstract

Two patients with advanced renal cell carcinoma underwent allogeneic hematopoietic stem cell transplantation and received cyclosporine (CSP) as part of their immunosuppressive therapy. Despite adequate renal function, both patients developed hyperkalemia. CSP was the only pharmaceutical agent to which this electrolyte abnormality could be attributed. Evaluation of renal tubule function suggested that CSP-associated isolated hyperkalemia resulted from tubular resistance to aldosterone. We propose that the presence of a single functional kidney may be a risk factor for isolated hyperkalemia due to CSP.

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