International Journal of Hematology

DOI: 10.1532/IJH97.04193 Pages: 100-105

Autoantigenic Epitopes on Platelet Glycoproteins

1. Osaka University, Department of Hematology and Oncology, Graduate School of Medicine C9

2. Toyonaka Municipal Hospital, Department of Internal Medicine

Correspondence to:
Satoru Kosugi
Tel: 81-6-6879-3871
Fax: 81-6-6879-3879
Email: yoshi@hp-blood.med.osaka-u.ac.jp

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Abstract

Chronic immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by early platelet destruction mediated by antiplatelet autoantibodies. Platelet membrane glycoproteins (GP), especially GPIIb-IIIa and GPIb-IX, contain major autoantigenic determinants in chronic ITP. Recent advances in the localization of autoantigens as well as in the detection of GP-specific antibodies have improved our understanding of the pathophysiology of the disease. The N-terminal globular head of GPIIb-IIIa, particularly the β-propeller domain in GPIIb, seems to play an important role as a hot spot for autoantigenic epitopes in chronic ITP.

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