International Journal of Hematology

DOI: 10.1532/IJH97.06022 Pages: 283-288

New Therapeutic Approach for Myeloid Leukemia: Induction of Apoptosis via Modulation of Reactive Oxygen Species Production by Natural Compounds

1. Keio University School of Medicine, Division of Hematology

Correspondence to:
Masahiro Kizaki
Tel: 81-3-5363-3785
Fax: 81-3-3353-3515
Email: makizaki@sc.itc.keio.ac.jp)

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Abstract

The therapeutic approach to acute myeloid leukemia is based on chemotherapy, but the side effects of the drugs used and various complications, including infections and bleedings, are sometimes fatal. Recently, imatinib mesylate has shown remarkable efficacy and less toxicity as a molecularly targeted therapy in patients with chronic myeloid leukemia. Natural products appear to be safer than the current chemotherapeutic drugs, and we have therefore sought out new potential agents from various natural compounds with the ability to induce the apoptosis of myeloid leukemic cells.

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